Cholesterol Research Today is a free monthly online journal that collates and summarizes the latest research about Cholesterol, including details on high cholesterol, hdl, ldl, diet, risks.

Statins utilisation pattern: a retrospective evaluation in a tertiary care hospital in Thailand.

Chaiyakunapruk N, Asuphol O, Dhippayom T, Poowaruttanawiwit P, Jeanpeerapong N

Center of Pharmaceutical Outcomes Research (CPOR) Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences Pharmaceutical Care Research Unit, Naresuan University Buddhachinnaraj Hospital, Phitsanulok, Thailand. nui@u.washington.edu

Published 9 March 2011 in Int J Pharm Pract, 19(2): 129-35.
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Articles on Cholesterol published 9 March 2011:

Statins utilisation pattern: a retrospective evaluation in a tertiary care hospital in Thailand.   Int J Pharm Pract, 19(2): 129-35.

[Abstract] [Full-text]

Articles on Cholesterol published 23 February 2011:

Association of high-density lipoprotein cholesterol with coronary heart disease risk across categories of low-density lipoprotein cholesterol: the atherosclerosis risk in communities study.   Am J Med Sci, 341(3): 173-80.

[Abstract] [Full-text]

Articles on Cholesterol published 21 February 2011:

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.   Biochem Pharmacol, 81(6): 819-24.

Organotins, including tri-butyltin chloride (TBTC), are widely used in agricultural and chemical industries and cause persistent and widespread pollution. TBTC has been shown to activate nuclear receptor retinoid X receptor (RXR)/PPARγ signaling by interacting with RXR to modulate adipogenesis. However, whether TBTC affects liver X receptor (LXR)/RXR activity and subsequently the expression of cholesterol mobilizing genes is not known. In this study, we evaluated the ability of TBTC to ... [Abstract] [Full-text]

Articles on Cholesterol published 14 February 2011:

National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants.   Lancet, 377(9765): 578-86.

[Abstract] [Full-text]

The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis.   Dev Biol, 351(1): 146-55.

Niemann-Pick C (NPC) disease is a lethal neurodegenerative disorder affecting cellular sterol trafficking. Besides neurodegeneration, NPC patients also exhibit other pleiotropic conditions, indicating that NPC protein is required for other physiological processes. Previous studies indicated that a sterol shortage that in turn leads to a shortage of steroid hormones (for example, ecdysone in Drosophila) is likely to be the cause of NPC disease pathology. We have shown that mutations in ... [Abstract] [Full-text]

Articles on Cholesterol published 10 February 2011:

Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.   J Neurochem, 116(5): 747-55.

It is well established that memory formation and retention involve the coordinated flow of information from the post-synaptic site of particular neuronal populations to the nucleus, where short and long-lasting modifications of gene expression occur. With age, mnemonic, motor and sensorial alterations occur, and it is believed that extra failures in the mechanisms used for memory formation and storage are the cause of neurodegenerative pathologies like Alzheimer's disease. A prime candidate ... [Abstract] [Full-text]

Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor.   J Neurochem, 116(5): 858-65.

Endocannabinoid signaling modulates a variety of neuroinflammatory and neurodegenerative diseases, mainly through the activation of type-1 and type-2 (CB(1)R and CB(2)R) cannabinoid receptors. CB(1)R is negatively regulated by membrane cholesterol, while CB(2)R is unaffected. Here, we identified in the transmembrane helix 7 of human CBRs a consensus sequence already known in other proteins as cholesterol recognition/interaction amino acid sequence and consensus pattern. As this motif is ... [Abstract] [Full-text]

Cholesterol asymmetry in synaptic plasma membranes.   J Neurochem, 116(5): 684-9.

Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different domains. A common characteristic of these membrane domains is their association with cholesterol. Lipid rafts and caveolae are examples of cholesterol enriched domains, which have attracted keen interest. However, two other important cholesterol domains are the exofacial and cytofacial leaflets of the plasma membrane. The two leaflets that ... [Abstract] [Full-text]

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