Cholesterol Research Today is a free monthly online journal that collates and summarizes the latest research about Cholesterol, including details on high cholesterol, hdl, ldl, diet, risks.

Efavirenz to nevirapine switch in HIV-1-infected patients with dyslipidemia: a randomized, controlled study.

Parienti JJ, Massari V, Rey D, Poubeau P, Verdon R,

Epidemiologie, Systemes d'Informations, Modelisation, Institut National de la Sante et de la Recherche Medicale U707, Paris, France. parienti-jj@chu-caen.fr

Many antiretroviral therapies, including efavirenz, are associated with increased serum concentrations of low-density lipoprotein cholesterol. In a small 52-week randomized study, we found that switching from efavirenz to nevirapine was associated with significantly decreased low-density lipoprotein cholesterol levels, compared with continuation of efavirenz therapy (P<.04). A switch to nevirapine was associated with no severe adverse events.

Published 20 June 2007 in Clin Infect Dis, 45(2): 263-6.
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