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Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

Drouillet P, Balkau B, Charles MA, Vol S, Bedouet M, Ducimetière P, The Desir Study Group

INSERM U780-IFR69, Villejuif, France. drouillet@vjf.inserm.fr

BACKGROUND AND AIM: A number of studies have investigated the role of dietary calcium in lipid metabolism and weight regulation, and the influence of dairy products on the incidence of insulin resistance syndrome. In this study we have examined the relationship between dietary calcium and the established parameters of the insulin resistance syndrome. METHODS AND RESULTS: The study population (n=4372) was taken from the DESIR (Data from the Epidemiological Study on the Insulin Resistance Syndrome) cohort. Data for parameters relating to the syndrome were recorded, including glucose, serum insulin, triglycerides, HDL-cholesterol, waist circumference and blood pressure. Total energy, calcium and alcohol intake were estimated using a food-frequency questionnaire. Relationships between dietary calcium density and the above parameters were analyzed by multiple linear regression models, adjusted for age, smoking, alcohol consumption and physical activity. From one quartile of calcium density to the next, mean systolic and diastolic blood pressures and insulin concentrations decreased in women by 0.9 mm Hg, 0.5 mm Hg and 2.4%, respectively, and HDL-cholesterol increased by 0.007 mmol/l (all p<0.05) after adjustment for age, smoking, alcohol intake and physical activity. In men, there was an increase of 0.2 kg/m(2) in the body mass index(BMI) and a decrease of 0.4 mm Hg in diastolic blood pressure (both p<0.05). CONCLUSIONS: These results confirm a beneficial association between dietary calcium and arterial blood pressure, insulin and HDL-cholesterol levels in women, whereas in men there was only a beneficial association with diastolic blood pressure.

Published 6 August 2007 in Nutr Metab Cardiovasc Dis, 17(7): 486-92.
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